Study finds autism to be inherited

[Staysafebro]

Association of Genetic and Environmental Factors With Autism

Key Points

Question  What are the etiological origins of autism spectrum disorder?

Findings  In a large population-based multinational cohort study including more than 2 million individuals, 22 156 of whom were diagnosed with ASD, the heritability of autism spectrum disorder was estimated to be approximately 80%, with possible modest differences in the sources of autism spectrum disorder risk replicated across countries.

Meaning  The variation in the occurrence of autism spectrum disorder in the population is mostly owing to inherited genetic influences, with no support for contribution from maternal effects.

[Staysafebro]

@infoseeker786 @JambaKrantu

[infoseeker786]

Sad bro.father ki autism unte kids kuda vastundi annamata

[Staysafebro]

18 minutes ago, infoseeker786 said:

Sad bro.father ki autism unte kids kuda vastundi annamata

Grandparents can also pass it on. Girls are generally not properly diagnosed as their autism spectrum is slightly different from boys. It is much easier to detect in boys. These Women with undetected autism will pass it on and if the kid is a boy then it shows up. 

[Beardman]

Mothers of autistic children: lower plasma levels of oxytocin and Arg-vasopressin and a higher level of testosterone.

Xu XJ¹, Shou XJ, Li J, Jia MX, Zhang JS, Guo Y, Wei QY, Zhang XT, Han SP, Zhang R, Han JS.

Author information

 

Abstract

BACKGROUND:

Autism is a pervasive neurodevelopmental disorder,thought to be caused by a combination of genetic heritability and environmental risk factors. Some autistic-like traits have been reported in mothers of autistic children. We hypothesized that dysregulation of oxytocin (OXT), Arg-vasopressin (AVP) and sex hormones, found in autistic children, may also exist in their mothers.

METHODS:

We determined plasma levels of OXT (40 in autism vs. 26 in control group), AVP (40 vs. 17) and sex hormones (61 vs. 47) in mothers of autistic and normal children by enzyme immunoassay and radioimmunoassay, respectively and investigated their relationships with the children's autistic behavior scores (Childhood Autism Rating Scale (CARS) and Autism Behavior Checklist (ABC)).

RESULTS:

Significantly lower plasma concentrations of OXT (p<0.001) and AVP (p<0.001), as well as a higher level of plasma testosterone (p<0.05), were found in mothers of autistic children vs. those of control. The children's autistic behavior scores were negatively associated with maternal plasma levels of OXT and AVP.

CONCLUSIONS:

These results suggest that dysregulation of OXT, AVP and/or testosterone systems exist in mothers of autistic children, which may impact children's susceptibility to autism.

[Staysafebro]

11 hours ago, Beardman said:

Mothers of autistic children: lower plasma levels of oxytocin and Arg-vasopressin and a higher level of testosterone.

Xu XJ¹, Shou XJ, Li J, Jia MX, Zhang JS, Guo Y, Wei QY, Zhang XT, Han SP, Zhang R, Han JS.

Author information

 

Abstract

BACKGROUND:

Autism is a pervasive neurodevelopmental disorder,thought to be caused by a combination of genetic heritability and environmental risk factors. Some autistic-like traits have been reported in mothers of autistic children. We hypothesized that dysregulation of oxytocin (OXT), Arg-vasopressin (AVP) and sex hormones, found in autistic children, may also exist in their mothers.

METHODS:

We determined plasma levels of OXT (40 in autism vs. 26 in control group), AVP (40 vs. 17) and sex hormones (61 vs. 47) in mothers of autistic and normal children by enzyme immunoassay and radioimmunoassay, respectively and investigated their relationships with the children's autistic behavior scores (Childhood Autism Rating Scale (CARS) and Autism Behavior Checklist (ABC)).

RESULTS:

Significantly lower plasma concentrations of OXT (p<0.001) and AVP (p<0.001), as well as a higher level of plasma testosterone (p<0.05), were found in mothers of autistic children vs. those of control. The children's autistic behavior scores were negatively associated with maternal plasma levels of OXT and AVP.

CONCLUSIONS:

These results suggest that dysregulation of OXT, AVP and/or testosterone systems exist in mothers of autistic children, which may impact children's susceptibility to autism.

Like I said, it is harder to detect in women and will pass down from them too. If it is undiagnosed, the uncorrected traits will be picked up by the kids. It is easier to detect in boys so statistically there are more boys who are autistic than girls.