Early Results of Study Hint Coronavirus May Be Less Virulent in India

[Anta Assamey]

Early Results of Study Hint Coronavirus May Be Less Virulent in India; Further Research Required

By IANS

3 days ago

TWC India

 

 

A coronavirus

(IANS)

As SARS-CoV2, the new coronavirus that causes the COVID-19 disease, keeps wreaking havoc globally, a new study has come out with the finding that there may be a unique mutation in the Indian genome that needs to be studied further in detail to see if it can affect the coronavirus.

The New Delhi-based International Center for Genetic Engineering and Biotechnology (ICGEB) has performed preliminary research on SARS-CoV2 genomes from different geographical origins—India, Italy, the US, Nepal and Wuhan in China—to identify the notable genomic features of coronavirus.

The analysis revealed that there is only a single host microRNA (miRNA) titled "hsa-miR-27b" that is uniquely targeting the India SARS-CoV2.

 

"Based on our analysis, we speculate an important regulatory role of 'miR-27b' in SARS-CoV2 infection. The contradictory treatment outcomes may be due to the presence of the miR-27b target in the Indian genome specifically," said the research supported by the Department of Biotechnology (DBT), Government of India and the Indian Council of Medical Research (ICMR).

According to Dr Dinesh Gupta, lead researcher of the study published in prepreint portal bioRxiv, which is yet to be peer-reviewed, the mutations they found are not country specific, but genome specific.

"The country names in this case indicate where the genome sequences are submitted from. If the mutations are in the genes that code for proteins important for binding, entry and/or replication, they may affect the survival of the virus," Gupta told IANS.

To gain further insights into host responses to viral infection, the research team predicted that antiviral host-miRNAs may be controlling the viral pathogenesis.

"Our analysis reveals nine host miRNAs which can potentially target SARS-CoV2 genes. Interestingly, the nine miRNAs do not have targets in SARS and MERS genomes. Also, 'hsa-miR-27b' is the only unique miRNA which has a target gene in the Indian SARS-CoV2 genome," the authors wrote.

However, the research has so far been done in one genome sequence from India, so it is too early to predict that novel coronavirus is less virulent in the Indian context.

"The microRNAs are present in all human beings. hsa-miR-27b is one of the six antiviral microRNAs that can potentially bind to virus genes and affect its activity," said Gupta.

"In our study, which is a purely computational one, we predicted that this microRNA binds to the SARS-Cov2 genome submitted from India. However, it is too early to comment on it because there is only one high coverage sequence from India, so far," the researcher told IANS.

The total number of coronavirus positive cases in India crossed 1,070 on Monday, including foreign nationals, with more than 940 active cases, the Union Health Ministry said.

According to the researchers, the specific genetic and miRNA spectrum should be considered as the basis of the treatment management.

The team also observed that each genome has unique mutations—except the genome from Nepal, which shares 100 per cent similarity with the Wuhan genome.

"We indeed need a detailed study on the preliminary results," said Gupta, adding that it has to be a combination of wider testing and physical distancing to help identify the infection and prevent its spread in India.

 

[Anta Assamey]

https://documentcloud.adobe.com/link/review?uri=urn%3Aaaid%3Ascds%3AUS%3A781abf1e-7d6c-46e3-ba29-416f1958f141

[Anta Assamey]

@Catabolite read it ... You might find it interesting ...

[ring_master]

Arearey ee vishayam teliyaka @Modi 21 days lockdown ichesaade

[perugu_vada]

Chalo india na aithe after apr-14 

[sri_india]

inka india lo lockdown etheyachu antavaa bruh ....

[Catabolite]

7 minutes ago, Anta Assamey said:

@Catabolite read it ... You might find it interesting ...

I saw something like this, I don't understand how though, the binding affinity of the receptor to ACE is low antaada? Ala ayite US lo use chestunna ACE inhibitors won't work for patients in India that well? 

[Anta Assamey]

8 minutes ago, perugu_vada said:

Chalo india na aithe after apr-14 

 

7 minutes ago, sri_india said:

inka india lo lockdown etheyachu antavaa bruh ....

Me gola paduganu .... lock ettaindi paracetamol esukomani kaadu daniki ardam ... Its just a study .... They need more data to say anything .... Its just reattach findings ante..

[Anta Assamey]

5 minutes ago, Catabolite said:

I saw something like this, I don't understand how though, the binding affinity of the receptor to ACE is low antaada? Ala ayite US lo use chestunna ACE inhibitors won't work for patients in India that well? 

According to the article aite kanuka ... May be the strain is different ... That is the reason anukunta .. But final ga point aite annadu kada.. MORE STUDY needed ani ... Akkaditho take everything crossed fingers ani ardam .. 

[Catabolite]

Just now, Anta Assamey said:

According to the article aite kanuka ... May be the strain is different ... That is the reason anukunta .. But final ga point aite annadu kada.. MORE STUDY needed ani ... Akkaditho take everything crossed fingers ani ardam .. 

Different strain sare, why it is less virulent than other strain I don't understand. 

[Anta Assamey]

Just now, Catabolite said:

Different strain sare, why it is less virulent than other strain I don't understand. 

Adhi akkada rayaledu vadu ... 

[Spartan]

Ante Indian people ki unna Gene lo unna one of the mutation will prevent easy reception of Covid into our blood stream ana kavi uddesham...

@Anta Assamey 

[DummyVariable]

Can’t risk. Shut down is best.

[bhaigan]

 

this means Indians have strong immune system

[Catabolite]

Just now, bhaigan said:

 

this means Indians have strong immune system

Wrong. It means the virus is less virulent.