Scoop: Inside the epic White House fight over hydroxychloroquine

[Pachhiboothu]

3 minutes ago, user789 said:

Didn’t mean it.. Don’t support T like pulkas support Nakka..You will loose respect..

individual bavalu vundali kaka...tappem ledu....kasta nijalu matladitey tappem ledu...mottam nakkism .jaffaism.t la matladitey tappu.

 

ABN gaani lekka roomulo trump thata pakkakey kurchoni   vinnattu news vesi...alreadu CNN/Nakkisanigi ABN/Jaffaism ki sakshi/Tism ki Tv9..endi kaka

sucker thata better than this

[Sucker]

Just now, Pachhiboothu said:

individual bavalu vundali kaka...tappem ledu....kasta nijalu matladitey tappem ledu...mottam nakkism .jaffaism.t la matladitey tappu.

 

ABN gaani lekka roomulo trump thata pakkakey kurchoni   vinnattu news vesi...alreadu CNN/Nakkisanigi ABN/Jaffaism ki sakshi/Tism ki Tv9..endi kaka

sucker thata better than this

Nee baadha yendi muthatha 

[Zuri]

5 minutes ago, perugu_vada said:

Before Ivermectin can be used to combat coronavirus, funding is needed to get it to pre-clinical testing and clinical trials.
 

entha time padutundho pre-clinical and clinical trials avvataniki ? @karthik25 @Catabolite

E clinical trials ayyi drug market loki ravalente which is called phase 4 chala time padthadhi like 15-20 years many factors involved. Everythig should be documented. Trials lo only one main rule untadhi “ if it is not documented it disnot happen” 4 groups untaye deug safety, research team, data managemnet team ani kalisi pan chestharu and teating motham world lo ekadina chwstharu like different hospitals lo.

phase 1 anedi chala takkuva human subjects ni teskuntaru once phase one is succesfully completed they will move on to phase 2 danlo 2a and 2b untadhi usually ga 2 success ithey chala chances untaye. Oka phase chala time avthadhi like 3-5 years ( general ga) . Urgent situations lo phase 2 or 1 lo suceess ina fda approve chesidhi use cheyataniki i think compassionate use antaru anukunta like ebola vachinapudu elane icharu. So ipudu vaccine kantey unna drugs ithene best like j and j hiv medication use chesthundhi covid ni treat cheyataniki vatiki enni years undav. Easy ga market loli vachesthaye and they domt need much testing and the same goes to generic drugs patient aipoina tarvtha. I think anti malaria drug will be a game changer and possibility of side effects unaye like deafness and. Heart diseases but anharki ravu atleast chala mandhi young patients survive avochu and i dont think lomb term ivaru hyd lo

mannolu icharu cocktail

of drugs vellu ento us lo emana drug ivakantey 100 rules untaye.

[Pachhiboothu]

2 minutes ago, Sucker said:

Nee baadha yendi muthatha 

kasta verify chesuko nuvvu kooda ABN lekka ,,thata bathrommlo em matladindo news vestey ela...ani DBian feeling

 

[DummyVariable]

23 minutes ago, chittimallu_14 said:

I dont know the basics of those... control group ante enti? 

Control Group  - the ones with placebo

Intervention Group-  the one that receives the treatment

 

[Zuri]

20 minutes ago, chittimallu_14 said:

I dont know the basics of those... control group ante enti? 

Trials lo compare cheyataniki experiment group ( who receives test drug) vs control group( vellaki dummy drug or test drug or no drug istharu) usuall ga control group lekapothey study bias idhi chala. Blinded study or unblinded untadhi blinded lo malli types untaye like ah trial lo participate chese human subject ki em drug teskunado telidhu like kothadha or just vitamin ichara or no drug( dummy) konni trials lo investigator ki kuda telidhu. Unblinded antey idharki telusu.

[RunRaajaRun123]

1 hour ago, ARYA said:

evidence leka povatam endi 1500 poeple in NYC have been treated successfully with HCQ kada

Doctors can prescribe it but experts cannot say it can cure corona virus without studies.

it can be used as off the label

[Thokkalee]

US lo parledu.. doctor prescribe chesthe thappA dorakavu.. 

thatha maata vini migatha countries lo andaru ee drug konukkuni veseskuntunnaru.. vallu sanka nakipotharu.. I guess they are trying this in India, Spain and other countries saying that US found success in using this drug.. 

[perugu_vada]

51 minutes ago, Zuri said:

E clinical trials ayyi drug market loki ravalente which is called phase 4 chala time padthadhi like 15-20 years many factors involved. Everythig should be documented. Trials lo only one main rule untadhi “ if it is not documented it disnot happen” 4 groups untaye deug safety, research team, data managemnet team ani kalisi pan chestharu and teating motham world lo ekadina chwstharu like different hospitals lo.

phase 1 anedi chala takkuva human subjects ni teskuntaru once phase one is succesfully completed they will move on to phase 2 danlo 2a and 2b untadhi usually ga 2 success ithey chala chances untaye. Oka phase chala time avthadhi like 3-5 years ( general ga) . Urgent situations lo phase 2 or 1 lo suceess ina fda approve chesidhi use cheyataniki i think compassionate use antaru anukunta like ebola vachinapudu elane icharu. So ipudu vaccine kantey unna drugs ithene best like j and j hiv medication use chesthundhi covid ni treat cheyataniki vatiki enni years undav. Easy ga market loli vachesthaye and they domt need much testing and the same goes to generic drugs patient aipoina tarvtha. I think anti malaria drug will be a game changer and possibility of side effects unaye like deafness and. Heart diseases but anharki ravu atleast chala mandhi young patients survive avochu and i dont think lomb term ivaru hyd lo

mannolu icharu cocktail

of drugs vellu ento us lo emana drug ivakantey 100 rules untaye.

@Zuri thnx for details, Ivermectin old drug ye kada, but it was used before for some other purpose like how malarial drug is being used now, so anni years padutunda to get fda approval to use Ivermectin for covid ? 

[DummyVariable]

2 minutes ago, Thokkalee said:

US lo parledu.. doctor prescribe chesthe thappA dorakavu.. 

thatha maata vini migatha countries lo andaru ee drug konukkuni veseskuntunnaru.. vallu sanka nakipotharu.. I guess they are trying this in India, Spain and other countries saying that US found success in using this drug.. 

Ante mana India lo doctors RMP doctors ana baa ... thellodu chebithe yeddulla follow ayipothara?

[perugu_vada]

3 minutes ago, Thokkalee said:

US lo parledu.. doctor prescribe chesthe thappA dorakavu.. 

thatha maata vini migatha countries lo andaru ee drug konukkuni veseskuntunnaru.. vallu sanka nakipotharu.. I guess they are trying this in India, Spain and other countries saying that US found success in using this drug.. 

Thaatha mata vini doctors enduku prescribe chestharu ? Asalu medicine shortage undi ga anni countries lo already

[perugu_vada]

Just now, DummyVariable said:

Ante mana India lo doctors RMP doctors ana baa ... thellodu chebithe yeddulla follow ayipothara?

Ante india lanti countries lo prescription lekapoina koneskovochu kada , but as it standb now i dont think it is any more available in medical shops 

[Thokkalee]

1 minute ago, perugu_vada said:

Thaatha mata vini doctors enduku prescribe chestharu ? Asalu medicine shortage undi ga anni countries lo already

This is not a patented drug.. US lo ee drug thayaru cheyyaru.. bcoz it is a very cheap generic medicine... Search this in goodrx.com US already has 29 million doses of this in its stockpile.. they want more.. so asking India now.. 

1 minute ago, perugu_vada said:

Thaatha mata vini doctors enduku prescribe chestharu ? Asalu medicine shortage undi ga anni countries lo already

India lo medicines ki trial phase emi Undadu kadaa.. most of the doctors prescribe medicines based on what they are marketed by the medical reps.. I have seen some govt circular suggesting that all medical workers working with the Covid patients to take this medicine every day.. not sure why 🤔 

[DummyVariable]

1 minute ago, Thokkalee said:

I have seen some govt circular suggesting that all medical workers working with the Covid patients to take this medicine every day.. not sure why 🤔 

Oori naayano

 

[Zuri]

13 minutes ago, perugu_vada said:

@Zuri thnx for details, Ivermectin old drug ye kada, but it was used before for some other purpose like how malarial drug is being used now, so anni years padutunda to get fda approval to use Ivermectin for covid ? 

Drug repurposing antaru time line ivalem bro but    New deug kantey takkuve untadhi antey not in months i guess many years avthaye. Mostly phase 2 success ithey fast track review untadhi same like premium processing laaga avi thousands of pages untaye documents avani review cheyatanike fda vadu general ga year pina teskuntadu. E news anni ivermectin and inka chala vasthaye small scale studies tarvtha population sample increase ithey chala criteria untadhi. Inka evanni chudaru e tym lo kinchem suceess ina release chestharu if they find if useful rest of the phases continue avthaye and market lo early ga release chesina anni sideffects monitor chestharu. Lets say malaria drug repu trump anatlu market loki release ithey isthey patients ki out of 50000 patients lo konchem mandhiki cure avochu konchem mandhiki life threating avochu deaths avochu evanni doctors or investigators safety team untadhi danne drug safety or pharmacovigilance antaru vallali report chestharu  vellu malli fda ki submit chestharu data antha. Like oka drug teskuntey dani valla use undha and benefit risk evaluation chi chestharu. Incase patient ki life threating condition lo untey e malaria drug isthey atleast life save cheyochu but not completely ani vunna ivochu. Depends on data chala untaye bro nenu chala genralize Chesi chepanu.