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Why the AstraZeneca-Oxford Covid-19 vaccine is different


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Among the Covid-19 vaccines furthest along in development, the AstraZeneca-Oxford candidate is most likely to be affordable to low- and middle-income countries. And considering much of the world’s population currently lives in low- and middle-income settings, it’s the shot that, if effective, is poised to make the biggest dent in the pandemic worldwide.

It uses a novel approach to inoculation, but one that’s different from Pfizer-BioNTech and Moderna — and from conventional vaccines.

The Moderna and Pfizer-BioNTech vaccines both use mRNA as their platform for delivering the genetic instructions. AstraZeneca-Oxford’s uses DNA instead, and the DNA is delivered to cells with the help of another virus known as an adenovirus.

AstraZeneca, unlike Moderna and Pfizer/BioNTech, has promised to sell its shot at cost — around $3 to $4 — and not to profit from the vaccine while the pandemic is ongoing.

 

Also unlike the two other leading vaccine candidates, it doesn’t require extremely cold temperatures for storage. The AstraZeneca-Oxford vaccine, however, can be stored in a normal refrigerator for at least six months.

 

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1 minute ago, sri_india said:

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