vaccine is how much safe

[PilliBeta]

23 minutes ago, Anta Assamey said:

 

Iddaru kalisi nanny ragging chestunaru ga.... I would defer the Knowledge sharing session to @PilliBeta ..  

mRNA is a very strong adjuvant. Most likely will activate everything in the immune system, mostly pDCs. Will result in a lot of type I interferon secretion, maybe even interferon lambda. Inta interferon secretion unte pakka high fever, and body pains guaranteed ani my opinion. It is not suitable if you have compromised immune system, or other underlying autoimmune diseases. Also there are studies that interferon secretion in high doses can be bad for pregnant woman, not sure how much validity it has to fetal immunity in context of covid vaccine. 

[PilliBeta]

13 hours ago, Spartan said:

i think it is coming from the news where..

Haryana MP took the first dose, and still became covid +ve..

the Dr has to say that, people will become immune only after second dose...

may be depends on how one's body reacts to the doses.

It takes atleast 2 weeks to develop immunity, the reason they have two doses is first dose is for priming of T cells, second dose is for boosting of immune memory. Second dose ivvakapote T cell memory undadu. 

[Amrita]

3 minutes ago, PilliBeta said:

mRNA is a very strong adjuvant. Most likely will activate everything in the immune system, mostly pDCs. Will result in a lot of type I interferon secretion, maybe even interferon lambda. Inta interferon secretion unte pakka high fever, and body pains guaranteed ani my opinion. It is not suitable if you have compromised immune system, or other underlying autoimmune diseases. Also there are studies that interferon secretion in high doses can be bad for pregnant woman, not sure how much validity it has to fetal immunity in context of covid vaccine. 

I heard about this. Also fertility problems vache chance undi ani vinna from  a colleague the other day . 

[Amrita]

19 minutes ago, Anta Assamey said:

My opinion... If you are healthy with no other diseases then go for it.... Nothing is going to happen ... If you are afraid of getting side effects that will be the case always even if you get COVID directly or if you are getting the vaccine in future... Think you are fortunate if you having access to the vaccine early and take it ... And avoid possible pain going through the COVID time ..

Parents ki okay na e vaccine ? They usually have pre existing conditions kada? 

[PilliBeta]

On 12/14/2020 at 11:29 AM, perugu_vada said:

high risk ante old-age.. and those who have health conditions vaalla ki ivvamani approve chesaru (but not to those who are  iinfected with covid, becos vaccine is preventive .. it is not therapeutic to treat the infected, oka sari infect ayi thaggithe obvious ga antibodies develop aithay, there is no point in giving vaccine to them)

Not true, infect ayina vallaki vaccine ivvadam risky in my opinion. For example, Trump ki Remedisivir icharu, anyone who gets Remedisivir should not be given vaccine because they are immunocompromised. 

[PilliBeta]

2 minutes ago, Amrita said:

I heard about this. Also fertility problems vache chance undi ani vinna from  a colleague the other day . 

Not sure about fertility problems, kani usually pregnant woman ki fetus chuttuta immune privileged site untundi, basically so the immune cells of the mother cannot hurt the fetus, but since interferon is just a cytokine (small molecule), at high concentrations, it can go inside the fetal site annadi study. 

[Amrita]

21 minutes ago, PilliBeta said:

Not sure about fertility problems, kani usually pregnant woman ki fetus chuttuta immune privileged site untundi, basically so the immune cells of the mother cannot hurt the fetus, but since interferon is just a cytokine (small molecule), at high concentrations, it can go inside the fetal site annadi study. 

I see. Thanks !

[perugu_vada]

47 minutes ago, PilliBeta said:

mRNA is a very strong adjuvant. Most likely will activate everything in the immune system, mostly pDCs. Will result in a lot of type I interferon secretion, maybe even interferon lambda. Inta interferon secretion unte pakka high fever, and body pains guaranteed ani my opinion. It is not suitable if you have compromised immune system, or other underlying autoimmune diseases. Also there are studies that interferon secretion in high doses can be bad for pregnant woman, not sure how much validity it has to fetal immunity in context of covid vaccine. 

 

45 minutes ago, PilliBeta said:

It takes atleast 2 weeks to develop immunity, the reason they have two doses is first dose is for priming of T cells, second dose is for boosting of immune memory. Second dose ivvakapote T cell memory undadu. 

 

42 minutes ago, PilliBeta said:

Not true, infect ayina vallaki vaccine ivvadam risky in my opinion. For example, Trump ki Remedisivir icharu, anyone who gets Remedisivir should not be given vaccine because they are immunocompromised. 

 

36 minutes ago, PilliBeta said:

Not sure about fertility problems, kani usually pregnant woman ki fetus chuttuta immune privileged site untundi, basically so the immune cells of the mother cannot hurt the fetus, but since interferon is just a cytokine (small molecule), at high concentrations, it can go inside the fetal site annadi study. 

 midi midi gnaanam tho chaala mandhi negativity spread chestunaru .. cant understand their logic though .. especially when ppl are dying 

[Anta Assamey]

2 hours ago, PilliBeta said:

Not true, infect ayina vallaki vaccine ivvadam risky in my opinion. For example, Trump ki Remedisivir icharu, anyone who gets Remedisivir should not be given vaccine because they are immunocompromised. 

Immune comprised not for ever kada... So eventually they will get the vaccine ....

Malli velu pettanu vaddu anukuntune ...

[vankay bomb]

16 hours ago, Amrita said:

Miru health worker ah ?

Yes

[PilliBeta]

1 hour ago, Anta Assamey said:

Immune comprised not for ever kada... So eventually they will get the vaccine ....

Malli velu pettanu vaddu anukuntune ...

I think there are some long term effects of Remedisivir. 

[PilliBeta]

3 hours ago, perugu_vada said:

 

 

 

 midi midi gnaanam tho chaala mandhi negativity spread chestunaru .. cant understand their logic though .. especially when ppl are dying 

We should all take the vaccine, but should still be careful, wearing masks and keeping distance. It's not going to get back to how it was. In my opinion it will be another decade by the time the last person on Earth is cured of COVID-19. 

[Sachin200]

3 hours ago, PilliBeta said:

Not true, infect ayina vallaki vaccine ivvadam risky in my opinion. For example, Trump ki Remedisivir icharu, anyone who gets Remedisivir should not be given vaccine because they are immunocompromised. 

So body will not produce antibodies ? 

[PilliBeta]

2 minutes ago, Sachin200 said:

So body will not produce antibodies ? 

Antibodies are not what is needed, T cell immunity is needed. Remedisivir iste immune system won't work, anduke covid patients ki idi icharu, because immune system was acting up and attacking heart, lungs or kidney. But ippudu vaccine ichetappudu immune system should work, but Remedisivir ichina vallaki immune system won't work, so vaccine won't work. 

[Anta Assamey]

1 hour ago, PilliBeta said:

I think there are some long term effects of Remedisivir. 

You are mixing up side effects with Immune suppression for life time ...