Calling PilliBeta

[AndhraneedSCS]

@PilliBeta

 

Which Vaccine is better?

Novavax

Oxford-Astrazeneca

Moderna

Pfizer

Bharat Biotech

 

[PilliBeta]

It's not like I tested all of them, I have no idea. I have an idea of what they do, but don't know which one is better. If it were my choice, I would take whichever is made available. 

[narsy]

lol

[PilliBeta]

For those of you interested in how a vaccine works and what cytokine storm is, here...took me a while to type. So, like share and comment. Subscribe for more information. 

1 hour ago, PilliBeta said:

The vaccine is first uptaken by myeloid cells called dendritic cells, they are everywhere in the skin. These cells are on the look out for anything foreign.

When they find something foreign, they process it (in this case the vaccine) and produce antigen. Then they go to the lymph node to find a T cell. Our body has T cells for every antigen you can possibly think of, so  the dendritic cell finds a T cell that has a receptor for that particular antigen. 

Once it finds the right T cells, it passes on the antigen to the T cells and the T cells are activated.

Once these T cells are activated, they expand and are produced in large numbers. Most of the T cells produced are effector T cells that leave the lymph node and go to the blood stream, they are always on alert to find the virus that matches the antigen they have. 

However most of the effector T cells die after the infection leaves the body (in this case the vaccine). When the infection is cleared, some of the T cells also become memory T cells and go to the bone marrow. In case of reinfection, they recognize the same antigen. 

 

The memory T cells go the lymph node and expand again to produce effector T cells, since effector T cells are the cells that can kill the virus. Memory T cells are self renewed in the bone marrow for later possible infections. 

 

27 minutes ago, PilliBeta said:

Cytokines are basically molecules that cells use to communicate and are the first response for most cells. A specialized subset of B cells called plasma cells produce antibodies specific to a virus. 

However, a lot of other innate cells like NK Cells, ILCs, pDCs also produce cytokines as the first defense mechanism (innate immune response).  

These innate cells (NK cells, ILCs, pDCs) have receptors on them that recognize cytokines. So, if one cell produces some cytokine, it is then sensed by other cells and they produce more of the same cytokine. It is kind of a feedback loop where all these cell produce tons of cytokine since they are all sensing the cytokine produced and producing more cytokine.  

In case of COVID, the patients that are admitted to the ICU are the ones that the innate immune response is so high that this feedback loop kept on creating more cytokine production, aka cytokine storm. 

In patients that are not admitted to the ICU, they might have an adaptive immune response involving T cells (see my previous comment). However, these patients may not have had the memory T cells in the bone marrow which is why they need to be vaccinated as well. 

 

 

[Telugodura456]

Go with covaxin in india. Traditional inactivated virus - known technology. And Bharat biotech isa good company - humble straightforward people. Rest are fancy technology - in india testing meeda doubts ee.

But Bharat already said covaxin has only 50% protection but still something,

[narsy]

8 minutes ago, PilliBeta said:

For those of you interested in how a vaccine works and what cytokine storm is, here...took me a while to type. So, like share and comment. Subscribe for more information. 

 

 

awww... 

[ammoru_talli]

@PilliBetasubscribe Ekkada ?

[narsy]

26 minutes ago, ammoru_talli said:

@PilliBetasubscribe Ekkada ?

quechen voddu, feel avvu.

tenet choosava? don't think, feel it. hehe..