AUTISM CAUSAL LINK ESTABLISHED

[CADNMALODU]

4 minutes ago, 11MohanRedddy said:

A person has to start a timer when the mouse starts sniffing and stop it when it stops. Single blinded - means the person who starts and stops the timer doesn't know which mice were give aluminum vs not. Double blinded - the person who is doing the analysis of the data doesn't know which mice started and stopped sniffing faster than the other. 

Double blind in conventional sense is when participants don't know what is being given to them. Any way, what bias are you implying in the data? 

[11MohanRedddy]

Just now, CADNMALODU said:

Double blind in conventional sense is when participants don't know what is being given to them. Any way, what bias are you implying in the data? 

If I am the student and I want the paper to be published, I will start the timer on control group earlier or vice versa. It is not a defined measurement like weight of the mouse or amount of sugar in blood etc. for behavioral studies without double blinded, p value of 0.04 is laughable.

[CADNMALODU]

8 minutes ago, 11MohanRedddy said:

If I am the student and I want the paper to be published, I will start the timer on control group earlier or vice versa. It is not a defined measurement like weight of the mouse or amount of sugar in blood etc. for behavioral studies without double blinded, p value of 0.04 is laughable.

And why do you want to start timer earlier ?

[11MohanRedddy]

8 minutes ago, CADNMALODU said:

And why do you want to start timer earlier ?

Because I am inherently biasing the study since I want to publish the study. It is very much so with behavioral studies if I know which group is what. That is why behavioral studies are usually captured on camera, and videos are analyzed by algorithms so that inherent bias is avoided. The person doing the analysis should not know the result, the person conducting the study should not know which group is what...double blinded study. Research ethics 101. 

[Jaggadonga]

1 hour ago, CADNMALODU said:

How was your susceptibility to flu, pre COVID vs Post COVID Vax ?

Do you see an increase in down time ? Fatigue? and any other parameters? 

 

A lot. Prior COVID I don't even care if I have symptoms. But now I will go completely down for 2 days with fever and cough will last for few weeks 

[CADNMALODU]

3 hours ago, 11MohanRedddy said:

Because I am inherently biasing the study since I want to publish the study. It is very much so with behavioral studies if I know which group is what. That is why behavioral studies are usually captured on camera, and videos are analyzed by algorithms so that inherent bias is avoided. The person doing the analysis should not know the result, the person conducting the study should not know which group is what...double blinded study. Research ethics 101. 

What is the inherent bias you're implying that made you start the timer ealier? Controls are examined under the same circumstances, right?  Besides, animal testing doesn't warrant double blinding. Even regulators don't ask for it. Double blinding is usual norm for clinical trials to New drug applications, even then there are cases where regulators accept open labelled studies as well. 

 

[CADNMALODU]

2 hours ago, Jaggadonga said:

A lot. Prior COVID I don't even care if I have symptoms. But now I will go completely down for 2 days with fever and cough will last for few weeks 

It's possible side effect of the mRNA Vax. I only can suggest you to stay away from flu Vax. Don't overburden your immune system. It only aggravates problems further.

[11MohanRedddy]

1 hour ago, CADNMALODU said:

What is the inherent bias you're implying that made you start the timer ealier?

It is called confirmation bias. It is common in behavioral studies. 

[CADNMALODU]

13 hours ago, 11MohanRedddy said:

It is called confirmation bias. It is common in behavioral studies. 

Confirmation bias is what you're thinking, but my question was why did you propose starting the timer earlier? Do you think this mitigates the confirmation bias? How?

[11MohanRedddy]

1 hour ago, CADNMALODU said:

Confirmation bias is what you're thinking, but my question was why did you propose starting the timer earlier? Do you think this mitigates the confirmation bias? How?

It seems to me that you have never done an experiment in your life clearly. Take a class on research ethics, and the answer is obvious. 

[CADNMALODU]

1 hour ago, 11MohanRedddy said:

It seems to me that you have never done an experiment in your life clearly. Take a class on research ethics, and the answer is obvious. 

Lol, i happened to spend more than decade in Pharmaceutical industry. I deal with animal tox and human study data day in and day out.  Anyways, why do you want to digress? Answer the question: how do you think starting timer earlier helps with the bias? 

[11MohanRedddy]

Just now, CADNMALODU said:

Lol, why do you want to digress? Answer the question, how do you think starting timer earlier helps with the bias? 

If I start the timer in the control group than in the aluminum group, then the aluminum group will be shorter time than the control group with a p value of 0.04. 

[CADNMALODU]

4 minutes ago, 11MohanRedddy said:

If I start the timer in the control group than in the aluminum group, then the aluminum group will be shorter time than the control group with a p value of 0.04. 

Huh? What gibberish is this? If you start the timer earlier, then the data collected will be unreliable. Its sort of data fabrication in itself. If you suspect bias in the data analysed, you need to pull the data points within the given data to point towards the bias. 

[11MohanRedddy]

9 minutes ago, CADNMALODU said:

Huh? What gibberish is this? If you start the timer earlier, then the data collected will be unreliable. Its sort of data fabrication in itself. If you suspect bias in the data analysed, you need to pull the data points within the given data to point towards the bias. 

Dude, read my previous comments again. I said that bias will be introduced if the experiment is not blinded. Did you not learn this in research ethics that behavior tests should be double blinded? At least single blinded. They don't even show the video of the mice, how do you know if was done without bias if the experiment is not blinded. Data fabrication is changing your data. This is not data fabrication. It is confirmation bias. Both are not same. 

[CADNMALODU]

1 hour ago, 11MohanRedddy said:

Dude, read my previous comments again. I said that bias will be introduced if the experiment is not blinded. Did you not learn this in research ethics that behavior tests should be double blinded? At least single blinded. They don't even show the video of the mice, how do you know if was done without bias if the experiment is not blinded. Data fabrication is changing your data. This is not data fabrication. It is confirmation bias. Both are not same. 

"Bias may" creep in doesn't mean it's a must. Second thing, Most of the animal studies data submitted to global government bodies are not blinded at all. Having the timer set early is direct attempt to fabricate the data. If you accuse data of bias, then you should point out to "data points" that you accuse of it, or the rigor of the data analysis, which selectively cherry picks on the data points.