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Sirna Therapeutics, Inc. has announced that it has selected Sirna-AV34, a systemically [url=https://www.yeezyy.at]yeezys 350[/url] delivered, chemically modified short interfering RNA compound, as its candidate for advancement to human clinical testing against Hepatitis C virus.Sirna completed its preclinical evaluation of the efficacy of Sirna- AV34 and has begun cGMP manufacturing for its Phase I clinical studies.聽 Sirna expects to init [url=https://www.adidas-yeezys.com.mx]yeezy slide[/url] iate IND-enabling toxicology studies in the first quarter of 2006 followed by the filing of an Investigational New Drug (IND) application with the U.S. Food and Drug Administration (FDA) by the fourth quarter of 2006.Sirna-AV34 is a systemically delivered, nanoparticle-based therapeutic targeting the Hepatitis C virus.聽 The compound consists of mult [url=https://www.nbbalance.de]nb[/url] iple individual, chemically modified, siRNA sequences which target conserved sequences in the Hepatitis C viral genome.Sirna-AV34 is designed to inhibit viral replication and reduce the selection of drug resistant mutant variants.聽 The design principl Islamabad has issued visas to 81 Hindu pilgrims to attend the 308th birthday celebrations of Shiv Avtari Satguru Sant Shadaram Saheb, the Press Trust of India reported on Monday.In an effort to improve people to people contact Pakistan issued the visas under the 1974 bilateral protocol. Taking 鈥渘ote of the sentiments and devotion of the various communities in the two countries for the historic and sacred shrines in the oth [url=https://www.valela.at]ugg fellboots[/url] er鈥? India and [url=https://www.adidascampus.com.de]adidas campus gr眉n[/url] Paki [url=https://www.adidas-samba-adidas.fr]adidas samba blanche[/url] stan have agreed on a set of principles for facilitating visits to such shrines.India detains dozens of Pakistani Hindu pilgrimsAs per the protocol, such visits from one country to the other shall be allowed without discrimination as to religion or sect and every effort should continue to be made to ensure that places of religious worship mentioned in the agreed list are properly maintained and their sanctity preserved.Published in The Express Tribune, November 22nd, 2016.

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Kdtt US accuses Pakistan of providing safe haven to militants
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Parkinson's disease, a neurodegenerative disorder that affects more than 6 million people worldwide, is caused by the buildup of alpha-synuclein proteins in the brain. The biological function of alpha-synuclein is still not well understood, but because of its role in neurodegenerative diseases, researchers are actively studying this protein to understand the mechanisms of the disease and to look for new treatment strategies.A new study from Elizabeth Rhoades and postd [url=https://www.nikeairforces.de]air force 1 herren[/url] oc Melissa Birol found that when alpha-synuclein binds to extracellular glycoproteins, proteins with added sugar molecules, it can be taken up by neurons more easily. The paper also identified a specific presynaptic protein, neurexin 1尾, as a key reg [url=https://www.adidas-yeezy.de]yeezys[/url] ulator in this process and a potential therapeutic target. Their findings were published in the journal PLOS Biology.In one possible model for the pathology of Parkinson's disease, bundles of alpha-synuclein proteins, known as aggregates, form ins [url=https://www.yeezy.com.mx]yeezy 350[/url] ide a neuron. This then leads t KARACHI:Bilawal Bhutto-Zardari and Asif Ali Zardari emerged as chairpersons of their respective factions of Pakistan Peoples Party (PPP) and PPP Parliamentarians (PPPP), respectively.The two-day-long int [url=https://www.adidascampus.com.de]adidas campus beige[/url] ra-party elections, held under convener Fouzia Habib at the party headquarters here, culminated in the election of former chairman Senate Nayyar Bukhari as secretary-general, Haider Zaman Qureshi as finance secretary and Chaudhry Manzoor Ahmed as information secretary.According to the party鈥檚 spokesperson, the party鈥檚 office-bearers reposed their trust and elected Bilawal Bhutto Zardari as chairman PPP. All office-bearers were elected for a period of 4 years.PPPP, which is parliamentary party in the National parliament, [url=https://www.nbbalance.fr]nb 530[/url] elected Asif Ali Zardari as its president, Farhatullah Babar as secretary-general, Saleem Mandviwalla as finance secretary and Maula Bux Chandio as information secretary.These elections were held under convener Farooq H. Na [url=https://www.inkwiz.se]ugg boots tasmania[/url] ek. Other members of the electoral body were Taj

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Ktkf Maalik ban is our lowest ebb
Helping people with addictions has beco [url=https://www.adidas-yeezys.fr]yeezy slides[/url] me a research passion for Purdue University's Richard van Rijn, who is leading a team to make drug discoveries to support [url=https://www.nike-dunks.de]nike dunk high[/url] millions around the world dealing with alcohol use disorders, chronic pain and mood disorders."These disorders are currently not adequately managed," said van Rijn, an assistant professor of medicinal chemistry and molecular pharmacology. "Better medications that take a mo [url=https://www.yeezyy.at]yeezy sneakers[/url] re holistic approach and produce fewer side effects will be beneficial. We have discovered that two peptides - which are naturally metabolic products of Rubisco, a large protein found in many plants like spinach - may aid in the development of these new medications."This discovery by the Purdue team provides a new avenue for the development of medications that provide therapeutic relief for a patient without causing unwanted side effects. The discovery is published in the Dec. 24 edition of European Neuropsychopharmacology."We are part of an exciting new area ISLAMABAD:In a bid to do away with waivers on account of Qisas and Diyat, the government has decided to amend several sections of the Pakistan Penal Code (PPC) and Code of Criminal Procedure (CrPC) to prevent honour killings.In Sharia law, Diyat is the financial compensation paid to the victim or heirs of a victim in the cases of murder, bodily harm or property damage. It is an alternative punishment to Qisas (equal retaliation).NA approves changes in criminal lawsThe two proposed anti-honour killings laws 鈥?Criminal Laws Amendment Bill, 2015, and the Anti-Rape Laws (Criminal L [url=https://www.adidas-samba-adidas.it]adidas samba vegan[/url] aws Amendment) Bill, 2015 鈥?could not be passed by th [url=https://www.adidas-samba-adidas.it]adidas samba adidas[/url] e National Assembly within the stipulated timeframe of 90 days.Both bills, initially moved by PPP鈥檚 former senator Sughra I [url=https://www.inkwiz.se]ugg boots tasmania[/url] mam in the Senate as private member鈥檚 bills, are now being pursued by Senator Farhatullah Babar. A consensus has already developed between the government and the opposition over an anti-rape bill while an agreement on the anti-honour killin

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Pucc Impact: ;Brexit will reduce remittance, exports;
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Ywqk Gaucher disease may protect against Parkinson s disease-related color visual impairment
Northwell Health鈥檚Division of Rheumatologyand the Feinstein Institutes for Medical Research announced today the results from the largest Phase 3 lupus nephritis clinical trial ever conducted. The study, known as the BLISS-LN trial, found positive results of the efficacy and safety of the drug belimumab in patients with active lupus nephritis, a condition that causes inflammation in the kidneys [url=https://www.nbbalance.de]new balance 574[/url] of patients with systemic lupus erythematosus (SLE).The groundbreaking results could lead to belimumab becoming the first drug approved by the Food and Drug Administration (FDA) to treat lupus nephritis, the most common severe complication of SLE that could lead to end-stage kidney disease.The landmark study, led byRichard Furie, MD, chief of the Divi [url=https://www.jordann.at]air jordan[/url] sion of Rheumatology at Northwell Health, published results in theNew England Journal of [url=https://www.adidas-yeezy.it]yeezy 500[/url] Medicine. The trial was conducted at 107 sites in 21 countries and included 448 randomized patients with biopsy-proven, active lupus nephritis. The participants ISLAMABAD:The top court has sought a reply from the federal government over the functioning of Strategic [url=https://www.nbbalance.fr]new balance homme[/url] Media Communication Cell (SMCC), led by Maryam Nawaz in the prime minister office, for promoting members of the ruling party and for criticizing those of the opposition on social and mainstream media.The two-jud [url=https://www.adidas-samba-adidas.es]adidas samba[/url] ge bench of the apex court, headed by Justice Ejaz Afzal Khan while hearing media commission case on Wednesday took strong exception over PEMRA for not restricting TV channels to allocate 10 per cent of total airtime to beam public service messages.鈥楴o to criticism鈥? PM addresses 鈥榝riendly media鈥橮EMRA chairman Absar Alam submitted that the managements of TV channels are opposing the PEMRA鈥檚 law, which restricts them to allocate ten percent time for social messages. Absar also stated that 350 cases against PEMRA are pending in high cour [url=https://www.campusadidas.it]adidas campus 00's[/url] ts. The bench was also surprised to know that working journalists have not been included in the regulatory authority and most of the members ar

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Jood Potential Alzheimer s Drug Discovered
A team of researchers led by scientists at the University of Toronto (U of T) has delayed the onset of amyotrophic lateral sclerosis (ALS) in mice. They are cautiously optimistic that the result, combined with other clinical advances, points to a potential treatment for ALS in humans.Commonly known as Lou Gehrig's disease, ALS is caused by the degeneration and loss of neurons that control muscles. There is no cure for ALS which currently affects between 2,500 and 3,000 Canadians."Our experiment profoundly delayed the disease by preventing the degeneration of neurons in the cortex of the brain," says Melanie Woodin, a professor in the Department of Cell &a [url=https://www.jordann.at]nike jordan4[/url] mp; [url=https://www.nikeairforces.de]air force schwarz[/url] Systems Biology (CSB) at U of T and a co-author of a study published recently in Brain."It delayed typical symptoms of ALS like the deterioration of motor skills and weight loss. It also increased the survival rate."The result was achieved in mice that possessed the same gene mutation (SOD1) found in some huma [url=https://www.adidas-yeezy.it]yeezy slides[/url] n ALS patients. The re WASHINGTON:Pre-season matches against star-studded Real Madrid and Barcelona were good preparation for t [url=https://www.nbbalance.es]newbalance 574[/url] he rigors of the Premier League even as they demonstrated the Spanish giants' superior level, Manchester United coach Jose Mourinho said Wednesday.With a goal from Brazilian striker Neymar, Barcelona defeated Manchester United 1-0 on Wednesday, handing the Red Devils their fi [url=https://www.nbbalance.es]nb 574[/url] rst defeat on the US Tour.It came on the heels of a penalt [url=https://www.campusadidas.fr]campus adidas[/url] y shootout victory over Real Madrid after the teams drew 1-1 in their International Champions Cup friendly match.Everton accept 拢75m bid for Lukaku: reportsIn terms of sheer talent, Mourinho acknowledged, Real Madrid and Barcelona have the edge."I think at this time, the best players are in these two clubs," he said. "We have to accept that as a reality. For us to play against both in a pre-season without any kind of pressure was very good for us."Both played with their best team 鈥?[it's] very, very good for us to measure against them," he saidThe Portugue

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MethylGene Inc. has announced the appointment of Rachel Humphrey, MD, to the post of Executive Vice President and Chief Medical Officer.Dr. Humphrey is board certified in Medical Oncology and has led the development of multiple oncology agents, two of which are currently commercialized (Nexavar庐 and YER [url=https://www.adidas-yeezys.com.mx]yeezys[/url] VOY庐)."Dr. Humphrey brings a wealth of drug development experience to MethylGene, and we look forward to her actively guiding our clinical developmen [url=https://www.dunks.fr]nike dunk sb[/url] t programs, particularly MGCD265 for the treatment of cancer and MGCD290 for the treatment of fungal diseases," said Charles Grubsztajn, President and CEO of MethylGene.Dr. Humphrey joins MethylGene from Bristol-Myers Squibb (NYSE: BMY), where she was most recently Vice President, Global Development Lead, Immuno-Onco [url=https://www.yeezyy.at]yeezy slide[/url] logy.From 2003 to 2011, Dr. Humphrey supervised a number of in-licensed and internal development programs including the Phase II - IV development of ipilimumab (YERVOY庐), which achieved global approval for the treatment of metast KARACHI:The Pakistan Telecomm-unication Authority (PTA) has formally invited applications from interested mobile phone service providers to participate in the auction for a 3G/4G mobile internet licence.The operators, including existing or new ones, may submit the application maximum by April 30, 2017, while the bidding would take place on May 12, 2017, the PTA announced.The interested participants would be provided consultation, ch [url=https://www.adidas-samba-adidas.it]adidas samba[/url] ange of rules and procedures, if any, and provided all the information they want to seek before they submit applications, PTA said.The telecom regulator has been tasked to sell the spectrum before the current fiscal year ends [url=https://www.stanleycups.fr]stanley-cup[/url] on June 30, 2017 so that this income may help the government to achieve the set, ambitious revenue target of Rs3.60 trillion for the year.The auction would be held for 10 MHz of spectrum in the 1,800 MGz band (Band 3) for technology neutral Next Generation Mobile Services (including 3G/4G and advanced generations) across Pakistan, [url=https://www.nbbalance.it]new balance donna[/url] PTA s

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The net proceeds to Aegerion from this offering are expected to be approximately $47.3 million, after deducting underwriting discounts and commissions. The offering is expected to close on June 19, 2012, subject to customary closing conditions.Jefferies & Company, Inc. and J.P. Morgan Securities LLC are acting as joint book-running managers in the offering. Leerink Swann LLC, Canaccord Genuity Inc., and Needham & Company, LLC are acting as co-managers for the offering. Aegerion has granted the underwriters a 30-day option to purchase up to an aggregate of 510,000 additional shares of common stock. Aegerion [url=https://www.nike-dunks.de]nike dunk low[/url] anticipates usin [url=https://www.dunks.fr]nike dunk sb[/url] g the net proceeds from the offering to fund activities directed at gaining approval of its New Drug Application submission with the U.S. Food and Drug Administration and Marketing Authorization Ap [url=https://www.nikeairforces.de]nike air forces[/url] plication submission with the European Medicines Agency for lomitapide as a potential treatment for homozygous familial hypercholesteremia (HoFH), pre-commercial and QUETTA:At least two people including a bomb disposal squad (BDS) officer were killed in an explosion near the overhead bridge on Quetta's Sariab road Monday evening.A security team was diffusing an improvised explosive device (IED) when the latter exploded. As a result, head of the squad, Commander Abdul Razzaq and police constable Abdul Majeed, were kil [url=https://www.nbbalance.it]nb 993[/url] led and 12 others, including policemen woun [url=https://www.inkwiz.se]ugg boots damen[/url] ded.The injured were shifted to the civil hospital.According to sources, the BDS team, on a tip-off, rushed to the site, and cordoned the area. However, the IED detonated during the diffusing process.Quetta's war widows Commander Abdul Razz [url=https://www.adidassamba.com.de]adidas samba rose[/url] aq of the BDS team, who was killed in the blast. PHOTO: EXPRESS

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Election as a Fellow is an honor bestowed upon AAAS members by their peers. This is the second consecutive year that eight UCSB faculty members have been named AAAS Fe [url=https://www.dunks.fr]nike dunk sb[/url] llows."This year's election of eight of our faculty colleagues as AAAS Fellows is a testament not only to their remarkable individual achievements and leadership in their fields, but also to the broad spectrum of outstanding research across the disciplines at UC Santa Barbara," said Chancellor Henry T. Yang."This prestigious honor is particularly meaningful because it represents a resounding affirmation from their peer [url=https://www.nike-dunks.de]dunks nike store[/url] s of the extraordinary contributions that each of these eight scholars has made to advancing the frontiers of science and serving our society. I join with our campus and community in proudly congratulating our new AAAS Fellows."The newly elected members from UCSB are:Lars Bildsten, professor and permanent member of UCSB's Kavli Institute for Theoretical Physics, for distinguishe [url=https://www.adidas-yeezys.es]yeezy 500[/url] d contributions to theoretical Pakistan has been consistent in its Human Development Index (HDI) ranking. It maintained its ranking of 147th amongst 188 countries in the latest HDI ranking and also had the distinction of being the last country in the medium development [url=https://www.adidas-samba-adidas.fr]adidas samba beige[/url] category. In South Asia, it beat Afghanistan in the ranking but was comfortably edged out by Bangladesh, Bhutan, Nepal, the Maldives and, of course, India and Sri Lanka. These reports have a predictable future in Pakistan. They are going to be archived without being read by policymakers; very few analysts will write on them; they are not [url=https://www.campusadidas.fr]adidas campus 80s[/url] going to make front-page headlines in the newspapers; they are not going to be breaking news on the electronic media; they will get minimal attention in the social media. Which, of course, means that next year the HDI ranking will [url=https://www.adidas-samba-adidas.fr]samba adidas og[/url] be either the same or lower. As they say if you keep on doing what you were doing yesterday, you will be where you were yesterday.So the question is: what have we been doing or not doing to

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