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New double mutant variant of SARS-CoV-2 found in 18 states, says Health Ministry

The ministry, however, said it could not be sufficiently established yet if these new variants were behind the recent spike in cases in India.

 

New double mutant variant of SARS-CoV-2 found in 18 states, says Health Ministry

A new "double mutant variant" of SARS-CoV-2 has been detected in India in addition to the several "variants of concern" that have already been found in at least 18 states, the Union Health Ministry said on Wednesday.

Some of these "variants of concern" had earlier been detected abroad.

The ministry, however, said it could not be sufficiently established yet if these variants were behind the recent spike in COVID-19 cases in some states.

It said genome sequencing by Indian SARS-CoV-2 Consortium on Genomics (INSACOG) has identified variants of concerns (VOCs) in several states and a new double mutant variant.

Genomic sequencing and epidemiological studies are continuing to further analyse the situation.

The Ministry of Health had established on December 25 INSACOG which is a grouping of 10 national laboratories for carrying out genomic sequencing and analysis of circulating COVID-19 viruses, and correlating epidemiological trends with genomic variants.

Genomic variants of various viruses are a natural phenomenon and are found in almost all countries, the ministry highlighted.

"Since INSACOG initiated its work, 771 variants of concerns (VOCs) have been detected in a total of 10,787 positive samples shared by states and UTs (union territories).

"These include 736 samples positive for viruses of the UK (B.1.1.7) lineage. Also,34 samples were found positive for viruses of the South African (B.1.351) lineage.

One sample was found positive for viruses of the Brazilian (P.1) lineage. The samples with these VOCs have been identified in 18 states of the country," the ministry said.

Genome sequencing and analysis have been carried out on samples from arriving international travellers, contacts of those positive for VOC and community samples from most of the states at INSACOG partner laboratories, it stated.

The analysis of samples from Maharashtra has revealed that compared to December 2020, there has been an increase in the fraction of samples with the E484Q and L452R mutations, the ministry said.

Such mutations confer immune escape and increased infectivity. These mutations have been found in about 15-20 percent of samples and do not match any previously catalogued VOCs, the ministry said.

"These have been categorized as VOCs but require the same epidemiological and public health response of increased testing, comprehensive tracking of close contacts, prompt isolation of positive cases and contacts as well as treatment as per National Treatment Protocol by the states and UTs," the ministry stated.

From Kerala, 2032 samples (from all 14 districts) have been sequenced. The N440K variant that is associated with immune escape has been found in 123 samples from 11 districts.

This variant was earlier found in 33 per cent of samples from Andhra Pradesh, and in 53 of 104 samples from Telangana. This variant has also been reported from 16 other countries, including the UK, Denmark, Singapore, Japan and Australia.

"As of now these can be at best said to be variant under investigation," the ministry said.

"Though VOCs and a new double mutant variant have been found in India, these have not been detected in numbers sufficient to either establish or direct relationship or explain the rapid increase in cases in some States," the ministry said.

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8 minutes ago, Kool_SRG said:

New double mutant variant of SARS-CoV-2 found in 18 states, says Health Ministry

The ministry, however, said it could not be sufficiently established yet if these new variants were behind the recent spike in cases in India.

 

 

 

New double mutant variant of SARS-CoV-2 found in 18 states, says Health Ministry

A new "double mutant variant" of SARS-CoV-2 has been detected in India in addition to the several "variants of concern" that have already been found in at least 18 states, the Union Health Ministry said on Wednesday.

 

 

Some of these "variants of concern" had earlier been detected abroad.

The ministry, however, said it could not be sufficiently established yet if these variants were behind the recent spike in COVID-19 cases in some states.

It said genome sequencing by Indian SARS-CoV-2 Consortium on Genomics (INSACOG) has identified variants of concerns (VOCs) in several states and a new double mutant variant.

Genomic sequencing and epidemiological studies are continuing to further analyse the situation.

The Ministry of Health had established on December 25 INSACOG which is a grouping of 10 national laboratories for carrying out genomic sequencing and analysis of circulating COVID-19 viruses, and correlating epidemiological trends with genomic variants.

Genomic variants of various viruses are a natural phenomenon and are found in almost all countries, the ministry highlighted.

"Since INSACOG initiated its work, 771 variants of concerns (VOCs) have been detected in a total of 10,787 positive samples shared by states and UTs (union territories).

"These include 736 samples positive for viruses of the UK (B.1.1.7) lineage. Also,34 samples were found positive for viruses of the South African (B.1.351) lineage.

One sample was found positive for viruses of the Brazilian (P.1) lineage. The samples with these VOCs have been identified in 18 states of the country," the ministry said.

Genome sequencing and analysis have been carried out on samples from arriving international travellers, contacts of those positive for VOC and community samples from most of the states at INSACOG partner laboratories, it stated.

The analysis of samples from Maharashtra has revealed that compared to December 2020, there has been an increase in the fraction of samples with the E484Q and L452R mutations, the ministry said.

Such mutations confer immune escape and increased infectivity. These mutations have been found in about 15-20 percent of samples and do not match any previously catalogued VOCs, the ministry said.

"These have been categorized as VOCs but require the same epidemiological and public health response of increased testing, comprehensive tracking of close contacts, prompt isolation of positive cases and contacts as well as treatment as per National Treatment Protocol by the states and UTs," the ministry stated.

From Kerala, 2032 samples (from all 14 districts) have been sequenced. The N440K variant that is associated with immune escape has been found in 123 samples from 11 districts.

This variant was earlier found in 33 per cent of samples from Andhra Pradesh, and in 53 of 104 samples from Telangana. This variant has also been reported from 16 other countries, including the UK, Denmark, Singapore, Japan and Australia.

"As of now these can be at best said to be variant under investigation," the ministry said.

"Though VOCs and a new double mutant variant have been found in India, these have not been detected in numbers sufficient to either establish or direct relationship or explain the rapid increase in cases in some States," the ministry said.

Lock down started ?

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COVID-19 INDIA as on : 26 March 2021, 08:00 IST (GMT+5:30) [↑↓ Status change since yesterday]
S. No. Name of State / UT Active Cases* Cured/Discharged/Migrated* Deaths**
Total Change since yesterday Cumulative Change since yesterday Cumulative Change since yesterday
1 Andaman and Nicobar Islands 6   4974 1  62  
2 Andhra Pradesh 3469 523  885209 231  7201 4 
3 Arunachal Pradesh 1   16785   56  
4 Assam 1736 17  215299 22  1104 1 
5 Bihar 925 198  261706 58  1567 2 
6 Chandigarh 2286 108  22702 115  368 3 
7 Chhattisgarh 13318 1384  314769 1020  4026 15 
8 Dadra and Nagar Haveli and Daman and Diu 92 22  3442 4  2  
9 Delhi 5497 607  636267 903  10978 5 
10 Goa 1278 122  55070 66  822 1 
11 Gujarat 9372 549  280285 1405  4473 7 
12 Haryana 7229 484  273276 562  3117 7 
13 Himachal Pradesh 1903 249  58684 64  1029 2 
14 Jammu and Kashmir 1593 80  125627 92  1983  
15 Jharkhand 1175 206  119698 72  1100  
16 Karnataka 18226 1321  947781 1192  12471 10 
17 Kerala 24690 112  1082668 1865  4539 12 
18 Ladakh 105 4  9713 2  130  
19 Lakshadweep 111 7  596 4  1  
20 Madhya Pradesh 11004 957  267242 919  3928 9 
21 Maharashtra 264001 15397  2283037 20444  53795 111 
22 Manipur 57 4  28936 1  374  
23 Meghalaya 23 1  13849 1  150 1 
24 Mizoram 24 6  4425   11  
25 Nagaland 4 2  12133   92 1 
26 Odisha 1132 142  336409 72  1919  
27 Puducherry 540 95  39521   679  
28 Punjab 21405 883  195015 1735  6517 43 
29 Rajasthan 5149 477  319933 238  2808  
30 Sikkim 40 3  6037 5  135  
31 Tamil Nadu 10487 741  850091 1027  12641 11 
32 Telengana 3995 311  299631 204  1683 3 
33 Tripura 44 1  33046 1  392  
34 Uttarakhand 1150 38  96215 153  1707 1 
35 Uttar Pradesh 5049 661  596451 165  8773 4 
36 West Bengal 3950 168  568115 344  10316 4 
Total# 421066 25874  11264637 32987  160949 257 
*(Including foreign Nationals)
**( more than 70% cases due to comorbidities )
#States wise distribution is subject to further verification and reconciliation
#Our figures are being reconciled with ICMR
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  • 3 weeks later...
COVID-19 INDIA as on : 13 April 2021, 08:00 IST (GMT+5:30) [↑↓ Status change since yesterday]
S. No. Name of State / UT Active Cases* Cured/Discharged/Migrated* Deaths**
Total Change since yesterday Cumulative Change since yesterday Cumulative Change since yesterday
1 Andaman and Nicobar Islands 89 1  5050 10  62  
2 Andhra Pradesh 23115 2161  898238 1091  7311 11 
3 Arunachal Pradesh 41 5  16791 1  56  
4 Assam 3734 485  216041 98  1118  
5 Bihar 17053 2357  267559 636  1616 6 
6 Chandigarh 3355 48  27412 375  400 1 
7 Chhattisgarh 98856 8579  352986 4865  5031 132 
8 Dadra and Nagar Haveli and Daman and Diu 501 107  3706 19  2  
9 Delhi 38095 3754  687238 7665  11355 72 
10 Goa 4565 243  57365 231  850 2 
11 Gujarat 30680 3112  317981 2854  4855 55 
12 Haryana 22487 1506  294930 2298  3282 14 
13 Himachal Pradesh 6069 700  63582 380  1124 9 
14 Jammu and Kashmir 7908 573  129439 418  2034  
15 Jharkhand 15343 1410  125175 937  1232 19 
16 Karnataka 76004 6760  985924 2767  12941 52 
17 Kerala 47914 3207  1120174 2474  4794 11 
18 Ladakh 721 109  10053 16  131  
19 Lakshadweep 75 13  737 1  1  
20 Madhya Pradesh 38651 3335  301762 3117  4221 37 
21 Maharashtra 566278 819  2834473 52312  58245 258 
22 Manipur 103 4  29035 22  376  
23 Meghalaya 193 4  13956 23  151  
24 Mizoram 175 32  4468 4  12  
25 Nagaland 167 10  12156 1  93  
26 Odisha 8774 1201  340600 538  1928 2 
27 Puducherry 2594 278  41268 232  693 2 
28 Punjab 27866 8  240798 3407  7559 52 
29 Rajasthan 36441 4455  330172 1291  2951 25 
30 Sikkim 161 8  6113 13  136  
31 Tamil Nadu 46308 4353  880910 2339  12927 19 
32 Telengana 24131 2267  306678 778  1772 7 
33 Tripura 298 55  33113 7  394  
34 Uttarakhand 7846 523  100533 804  1767 7 
35 Uttar Pradesh 81576 10335  614819 3197  9224 72 
36 West Bengal 26531 2550  582462 1947  10414 14 
Total# 1264698 63689  12253697 97168  171058 879 
*(Including foreign Nationals)
**( more than 70% cases due to comorbidities )
#States wise distribution is subject to further verification and reconciliation
#Our figures are being reconciled with ICMR
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TG lo erripu gadu asalu real Covid numbers release cheyatledu .. veediki gattiga oka debba padakapothe inka aapaleru .. vaadu em ante adhe right la saaguthondi

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9 minutes ago, perugu_vada said:

TG lo erripu gadu asalu real Covid numbers release cheyatledu .. veediki gattiga oka debba padakapothe inka aapaleru .. vaadu em ante adhe right la saaguthondi

Aalladhemundhi GUJ kuda super level lo under reporting...Also Vaccine wastage lo TG & AP are top two states till date.

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